Papers on "Polycomb Regulation of Embryonic Stem Cell Differentiation" and similar term paper topics
Paper #104238 ::
Polycomb Regulation of Embryonic Stem Cell Differentiation
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A discussion of polycomb regulation of embryonic stem cell differentiation and its potential as a cure for degenerative diseases.
Written in 2006; 3,470 words; 13 sources; APA;
$ 97.95
Paper Summary:
This paper takes a look at the functioning of embryonic stem (ES) cells, with particular focus on polycomb regulation. It maintains that ES cells are of great importance as they have the flexibility to give rise to any cell type in the body. It also adds that they can also be kept in an undifferentiated state and selectively induced to form any specialized cell types, which could potentially replace cells lost or damaged by disease. The paper points out that such knowledge has immense significance as it can help people who are suffering from various degenerative diseases or other tragedies. The paper includes charts, graphs and illustrations. It concludes that future studies are required to delve further into the not fully understood mechanisms by which ES cells self-renew, while maintaining the ability to differentiate into virtually all adult cell types.
Outline:
Experimental Procedures
Cells and Cell Culture
Chromatin Immunoprecipitation and DNA Microarray Analysis
Gene Expression Analysis
Future Experiments
From the Paper:
"Polycomb silencing mechanisms were first discovered in Drosophila as functions essential for the regulated expression of homeotic genes during development (Lewis, 1978). The Polycomb gene of Drosophila is a member of a large class of genes required for the segment-specific repression of homeotic selector genes (Paro & Hogness, 1991). PcG and their complexes are essentially conserved from insects to mammals. PcG genes do not constitute a family, but a diverse group originally defined by the fact that loss of function of each member has similar consequences in depression of the homeotic genes. Molecular analysis has shown that most PcG gene products act together to form multi-protein complexes (Berger, 2006)."
Tags:
molecule embryo fetus gene
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