Neoplastic Cell Migration

Paper Summary:

This paper examines how neoplastic cells have a wide range of mechanisms available to them in the process of metastasis and invasion and how such techniques include both individual cell movement and collective cell migration strategies. It also looks at how the ability for cancer cells to modify their migration mechanisms has resulted in a significant decrease in efficacy of anti cancer therapeutics designed against target adhesion receptors and proteases.
Outline
Introduction
Five Step Model
Diversity in Neoplastic Cell Migration
Single Cell Migration
Amoeboid
Mesenchymal
Chain
Collective Migration
Plasticity in Migration
Epithelial-Mesenchymal
Mesenchymal-Amoeboid
Collective-Amoeboid
Conclusion
References

From the Paper:

"The cell migration is a universal process in metastasis which involves many different mechanisms depending upon tissue environments and cell types. Broadly these cell movement patterns may be classified as single cell migration - amoeboid and mesenchymal - or collective migration - cell strands, sheets and clusters. A number of key molecular determinants are associated with cell movement strategies, such as the specific structure of the actin cytoskeleton (Cramer, 1999), the expression of integrins, matrix metalloproteinases and serine proteases (matrix-degrading enzymes) (Friedl, 2000), cadherins and activated leukocyte adhesion molecules (cell to cell adhesion molecules) and cytoskeleton signaling performed by RHO GTPases (Somlyo, 2003). There can be major changes to the mechanism of metastasis in response to the changing pattern of these specific molecular signals."

More papers on Neoplastic Cell Migration:

• Case Study # 91350 : "Migration from Traditional to Internet Distribution"
• Term Paper # 87202 : "Migration Patterns in Canada"
• Essay # 84388 : "Field to Factory: The Great Migration"

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